MOTS-C

MOTS-C is a 16-amino-acid peptide encoded within the mitochondrial genome, in the 12S rRNA region of mitochondrial DNA. It is one of the most actively studied compounds in research on mitochondrial-derived peptides, with published work on metabolic regulation, insulin sensitivity, exercise physiology, and age-related metabolic decline.

About the Compound

MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) was identified and characterized by Pinchas Cohen and colleagues at the USC Leonard Davis School of Gerontology. It belongs to an emerging class of mitochondrial-derived peptides studied as endocrine signaling molecules, with proposed regulatory roles in metabolism, insulin sensitivity, and cellular stress response.

Research has examined its proposed role in glucose homeostasis, exercise capacity, age-related metabolic decline, and the AMPK signaling pathway central to cellular energy regulation. Unlike the Khavinson bioregulator series, MOTS-C has a substantial and growing Western research base with published work from multiple academic institutions.

Research Areas

• Metabolic regulation. Published research has examined MOTS-C effects on glucose metabolism, insulin sensitivity, and AMPK pathway activation in cellular and animal models, including work from the Cohen laboratory at USC.
• Exercise physiology. Studies have investigated MOTS-C plasma levels in response to exercise and its potential role as an exercise-mimetic signaling molecule.
• Age-related decline. Research has documented decreases in circulating MOTS-C with age and examined effects of MOTS-C administration on age-related metabolic markers in animal models.
• Mitochondrial function. Studies have examined effects on mitochondrial biogenesis and function in skeletal muscle and other metabolically active tissues.

MOTS-C has a stronger independent research base than many other peptides in this catalog, with published work from multiple groups. Human clinical research remains limited.

Specifications

• Compound: MOTS-C
• Length: 16 amino acids
• Origin: Mitochondrial-derived peptide encoded in 12S rRNA region
• Molecular weight: approximately 2174 Da
• Form: Lyophilized powder, sealed glass vial
• Size: 20mg
• Purity: ≥98% by HPLC, batch-verified
• Identity: Mass spectrometry confirmation per batch
• Endotoxin: LAL assay per batch, reported on COA
• Storage: −20°C sealed; 4°C after reconstitution, used within 28 days
• Manufacturing: United States
• Testing: Independent ISO 17025-accredited laboratory, batch-specific
• Shipping: Temperature-controlled with insulated packaging

The Standard

Every batch of FeelGood MOTS-C is manufactured in the United States and tested by an independent ISO 17025-accredited laboratory before release. The certificate of analysis specific to your lot ships with the order.

Sold as a research chemical for laboratory and research purposes only. Not intended for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.